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Methods Course - "Structural Studies in Modern Biology"

Basic hands-on training in X-ray crystallography, SAXS, modeling and simulations

How can we use structural techniques to explain biological phenomena. Basic insights in X-ray crystallography, SAXS, modeling and simulations.

This course is addressed to PhD students in life science within the HHU.

Lecturers: Elisa Costanzi, Jens Reiners, Christoph Gertzen


Date : 12th to 16th of June 2023, 09:00 am until 17:00 pm

Room: 25.41.00.26 (ZIM) and CSS labs (26.24.01.024)

Number of participants: 16

Deadline for application: 15.05.2023

 

 

Topics of the course:

  • what can the techniques used for
  • introduction and basics for X-ray crystallography, SAXS and Modeling
  • sample quality for X-Ray and SAXS, buffer requirements and limitations.
  • practical sessions about selected topics in X-ray crystallography and SAXS
  • data evaluation and analysis
  • what can you learn from these data
  • introduction to modeling techniques and different tools
  • assessing model quality
  • practical sessions about how to get a protein model
  • presentation of advanced techniques, e.g., docking, MD, QSAR
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